Champions League results: Heung-min Son stars for Tottenham in 4-0 thrashing of Red Star Belgrade, ten-man Manchester City held by Atalanta
Giovano Lo Celso also scored on his full debut for Spurs as they came away with a 4-0 victory.
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Tottenham took the lead in Serbia but only after a crazy passage of play.
Kane hit the post with an initial effort before Son saw his shot blocked on the goal line by a Red Star defender.
The ball looped up to the far post when Tanguy Ndombele deflected the clearance, which Kane hit on the volley first time. The effort was heading wide but Son was sliding in at the far post, only to see ball bounce off his thigh and off the underside of the crossbar and bounce clear.
However, Lo Celso was on hand in the six-yard box to knock in the rebound to mark his first start with a goal.
Spurs were lucky not to be level on the stroke of half-time.
Former Huddersfield winger Rajiv Van La Parra burst into the penalty but his effort was saved onto the post by Paulo Gazzaniga and back into play.
However, a recovering Davinson Sanchez inadvertently hit the ball back towards his own goal and off the crossbar before Pochettino’s side finally cleared the danger.
Spurs hit Red Star on break in the 57th minute to double their advantage in Belgrade.
Tanguy Ndombele burst through midfield before finding Dele Alli on the edge of the area, who was composed enough to slot in Son to lash home into the top corner.
Spurs made it 3-0 just four minutes later with Son tapping in at the far post.
A neat pass sent Rose free on the left-hand side of the penalty before drilling a cross to the South Korea to slot home his second goal of the evening.
Christian Eriksen then added a fourth to make it a good night for Mauricio Pochettino’s side.